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Number of local repositories
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0402U002735,
к.б.н.
18-09-2002
o
The features of chromatine proteins oxidative modification of liver and Heren’s carcinoma cells in prior irradiated tumour bearing rats
Khuda Lidiya Victorivna,
popup.head Marchenko M.M.
popup.opponent Цудзевич Б.О.
popup.opponent Виноградова Р.П.
Об’єкт – онкогенез за умов передуючого трансплантації фракціонованого рентгенівського опромінення в сумарній дозі 25,3 мКл/кг. Мета - дослідження впливу низьких доз опромінення на процеси окиснювальної модифікації білків, Са,Мg-залежного ендонуклеолізу та включення радіоактивного попередника в РНК печінки і карциноми Герена пухлиноносіїв. Методи – біохімічні. Результати - вплив опромінення тварин перед імплантацією їм карциноми проявляється на початковому етапі росту новоутворення посиленням окиснення білків хроматину, накопиченням полідезоксирибонуклеотидів та зниженням синтезу РНК ядер клітин печінки. На подальших етапах онкогенезу динаміка досліджуваних процесів в печінці опромінених тварин цілком зумовлена ростом новоутворення. В клітинах карциноми Герена опромінених щурів найсуттєвіших змін зазнає процес карбонілювання гістонів, інтенсивність якого підвищена в перший тиждень після трансплантації. Галузь-біохімія, медицина
2002-09-18
2020-04-04
Updated: 2025-12-07
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