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0405U003923,
к.б.н.
18-10-2005
o
Influence of pirolimidazole and methylxanthine derivative on ТТХ-sensitive and ТТХ-resistant sodium channels in dorsal root ganglion neurons of rats.
Yatsenko Lyudmila Nikolaevna,
popup.head Fedulova Svetlana Anatolievna
popup.opponent Малишева Маргарита Костянтинівна
popup.opponent Любанова Ольга Петрівна
Об'єкт дослідження - натрієві канали ноцицептивних нейронів. Мета - з'ясувати дію похідних піролімідазолу та метилксантинів на натрієві струми ноцицептивних нейронів. За допомогою методів внутрішньоклітинного діалізу і фіксації потенціалу досліджено вплив на ТТХ- чутливі та ТТХ- стійкі натрієві канали нового анальгетика Д57 і встановлено, що Д57 дозо-залежно блокував їх обидва типи, та його дія характеризувалася різною спорідненістю і стехіометрією зв'язування. Блокуючий ефект Д57 залежав від частоти стимуляції, підтримуючого потенціалу і типу каналу. Показано, що похідні метилксантинів є агоністами натрієвих каналів і здійснюють свої ефекти шляхом прямої взаємодії з каналом, при цьому метильні групи не беруть участі в їх дії. Сфера використання: науково-дослідні та учбові установи медичного та біологічного профілю.
2005-10-18
2020-04-04
Updated: 2025-12-07
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