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0407U002558,
к.мед.н.
29-05-2007
o
Condition of aggregative capacity of platelets in patients with chronic inflammatory lung disease
Merenkova Evgeniya Oleksandrivna,
popup.head Gavrisyuk Volodymyr Kostyantynovych
popup.opponent Мостовий Юрій Михайлович
popup.opponent Дудка Петр Федорович
У дисертації викладені матеріали дослідження агрегаційної здатності тромбоцитів методом лазерної агрегометрії у 131 хворого на хронічні запальні захворювання легень. Встановлено, що у хворих неспецифічними запальними захворюваннями легень, туберкульозом з вираженими ознаками активності запального процесу, злоякісними новоутвореннями легень спостерігається підвищення агрегаційної здатності тромбоцитів. У хворих хронічним обструктивним захворюванням легень та ідіопатичним фіброзуючим альвеолітом поряд із гіперагрегацією тромбоцитів виявлено значне число гіпоагрегації. При дослідженні впливу на агрегацію тромбоцитів in vitro препаратів фенспірид, сорбілакт та реосорбілакт доведений їх антиагрегаційний ефект. Запропоновано використовувати метод лазерної агрегометрії з метою вивчення антиагрегаційних властивостей лікарських препаратів. Встановлено, що показники спонтанної агрегації тромбоцитів характеризуються досить слабкою відтворюваністю. Доведено, що підвищена агрегаційна здатність тромбоцитів спостерігається у пацієнтів зі збільшенням гемоконцентрації. Запропоновано даній групі хворих проводити інфузійну терапію реосорбілактом.
2007-05-29
2020-04-04
Updated: 2025-12-07
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