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0409U000222,
к.мед.н.
17-12-2008
o
Comparative estimation of the methods of adjuvant poly-chemotherapy in the complex treatment of breast cancer (randomized study).
Butenko Evgen Viktorovych,
popup.head Sedakov Igor Evgenovych
popup.opponent Шевченко Анатолій Іванович
popup.opponent Коссе Валентин Анатолійович
Об'єкт - методи ад'ювантної поліхіміотерапії (ПХТ) операбельного раку молочної залози (РМЗ). Мета - поліпшити віддалені і безпосередні результати лікування РМЗ шляхом застосування ад'ювантної внутрішньоартеріальної (в/а) ПХТ. Методи - ультразвукове дослідження, рентгенологічні, остеосцинтиграфія, комп'ютерна томографія, імуногістохімічні, патогістологічні, клініко-лабораторні, статистичні. Новизна - доведено низьку токсичність в/а введення хіміопрепаратів у хворих на РМЗ. На підставі рандомізованого дослідження доведено більшу ефективність ад'ювантної в/а ПХТ, порівняно з ад'ювантною системною ПХТ. Результати - розроблений метод ад'ювантної в/а ПХТ дозволив розширити показання до виконання органозберігаючих операцій у радикальному обсязі, зменшив кількість локорегіонарних рецидивів, збільшив період безрецидивного перебігу і загального кумулятивного виживання. Способи комплексного лікування РМЗ з використанням ад'ювантної в/а ПХТ, розроблені на кафедрі онкології ДонНМУ, впроваджені в практику Донецькогообласного протипухлинного центру, Дніпропетровського обласного онкологічного диспансеру, Міського міжрайонного онкологічного диспансеру м. Маріуполь, Міського онкологічного диспансеру м. Горлівки. Галузь - медицина (онкологія).
2008-12-17
2020-04-04
Updated: 2025-12-08
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