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0409U000308,
к.мед.н.
24-12-2008
o
Age changes of adenohypophysis under the normal environment condition, the cronic lead intoxication and during correction.
Rogozina Olga Vladimirovna,
popup.head Kashirina Nadezhda Konstantinovna
popup.opponent Корольов Віталій Олександрович
popup.opponent Волков Костянтин Степанович
Дисертація присвячена вивченню вікових змін в аденогіпофізі в звичайних умовах середовища, під впливом хронічної свинцевої інтоксикації та при застосуванні фармакологiчних препаратiв. За допомогою комплексу морфологічних методів (світлова, електронна мікроскопія, морфометрія) проаналізовано вікові особливості будови аденоцитів, встановлено, що хронічна свинцева інтоксикація викликає як дистрофічні та деструктивні зміни аденогіпофізу, так і репаративні процеси, ступінь яких залежить від тривалості надходження ацетату свинцю. Проведені дослідження виявили кількісні показники, які характеризують ушкодження і відповідні адаптаційні реакції, забезпечують фазність реагування аденоцитів. Застосування а-токоферолу при свинцевій інтоксикації значно зменшує деструктивні зміни, але найбільшу протекторну дію на структуру аденогіпофізу забезпечує ербісол.
2008-12-24
2020-04-04
Updated: 2025-12-07
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