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0411U000355,
к.вет.н.
20-01-2011
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Pathomorphological characteristics of pyrrolizidinoalkaloid's nephropathologies in cattle.
Zakharjev Andrey Victorovich,
popup.head Сhshetinskiy Igor Mykhailovich
popup.opponent Красніков Геннадій Андрійович
popup.opponent Яценко Іван Володимирович
Викладено основні результати вивчення нефропатологій у великої рогатої худоби при отруєнні піролізидиновими алкалоїдами чорнокореня лікарського та жовтозілля лучного. Проведено аналіз польових випадків і експериментальних отруєнь. При отруєнні у нирках розвиваються: функціональна ниркова гіпертрофія, нефротичний гострий некроз канальців, нефроз з тубулорексисом, гломерулонефротубулонекроз. Характер піролізидиногенних нефропатологій залежить від процесів, які розвиваються у печінці тварин, що отруїлися алкалоїдами. Функціональна ниркова гіпертрофія розвивається внаслідок виведення з організму метаболітів алкалоїдів, нефротичний гострий некроз канальців - в результаті дії на нирки метаболітів і невеликої кількості алкалоїдів, гломерулонефротубулонекроз - в результаті печінкової недостатності, що викликана алкалоїдами, на нирку діють як самі алкалоїди, так і їх метаболіти. Під впливом уведення екзогенного альбуміну важкість піролізидиногенних нефропатологій пом'якшується.
2011-01-20
2020-04-04
Updated: 2025-12-07
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