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0411U006260,
к.фарм.н.
28-10-2011
o
Development of composition and technology for malonic acid N,N? - dibenzylamide containing suppositories
Trunova Tetyana Valeriyivna,
popup.head KRUTS'KYKh TETYaNA VASYLIVNA
popup.opponent СТРЕЛЬНИКОВ ЛЕОНІД СЕМЕНОВИЧ
popup.opponent БОРЩЕВСЬКА МАРИНА ІЛЛІНІЧНА
Розроблено науково-методичний підхід до створення супозиторіїв протисудомної дії для лікування епілептичних захворювань. Теоретично та експериментально обґрунтовано склад препарату у вигляді супозиторіїв з дибамком (N,N? - дибензиламідом малонової кислоти). На підставі комплексних біофармацевтичних, фізико-хімічних, фармако-технологічних і біологічних досліджень розроблено оптимальну технологію і методи стандартизації супозиторіїв. Досліджена стабільність супозиторіїв під час зберігання. Проведені доклінічні дослідження розроблених супозиторіїв під умовною назвою "Супозиторії з дибамком". Доведена специфічна активність та нешкідливість препарату.
2011-10-28
2020-04-04
Updated: 2025-12-07
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