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0411U006548,
к.вет.н.
17-10-2011
o
The antiviral properties of chemical substances on the equine herpesvirus I type model
Zoz Olga Stepanovna,
popup.head Klestova Zinaida Sergeevna
popup.opponent Мазур Тетяна Василівна
popup.opponent Синицин Віталій Анатолійович
Наведено матеріали щодо біологічних властивостей трьох референтних штамів герпесвірусу коней І типу та зміни їх інфекційних властивостей у різних біологічних системах (перещеплюваних культурах клітин тваринного походження). Наведено розроблену схему первинного скринінгу противірусних речовин у системі in vitro. Встановлено цитотоксичні та противірусні властивості нових синтетичних похідних порфіринів та відомих фармацевтичних препаратів (ацикловір, амізон та індометацин) і їх композицій щодо ГВК І типу в системі in vitro. Вивчено співвідношення даних цитотоксичності дослідних хімічних речовин у системі in vitro та результати дослідження гострої токсичності в системі in vivo.
2011-10-17
2020-04-04
Updated: 2025-12-08
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