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0412U002345,
к.б.н.
20-04-2012
o
Morphofunctional changes of atria and auricles of heart in experimental thermal trauma and after lyophilized xenodermografts using.
Getmanyuk Iryna Bogdanivna,
popup.head Volkov Kostyantin Stepanovych
popup.opponent Боднар Ярослав Ярославович
popup.opponent Сарафинюк Лариса Анатоліївна
Дисертація присвячена вивченню закономірностей структурної перебудови передсердь і вушок серця при експериментальній термічній травмі та в умовах закриття опікової рани ліофілізованими ксенодермотрансплантатами. В експерименті на морських свинках встановлено, що тяжка опікова травма викликає значні морфофункціональні зміни в передсердях та вушках серця на різних рівнях їх структурної організації, ступінь ураження яких залежить від терміну експерименту та розвивається на фоні зростання токсичності плазми крові. В стадіях опікового шоку та ранньої токсемії в структурах серця розвиваються пристосувально-компенсаторні процеси, а в стадіях пізньої токсемії та септикотоксемії – наявні глибокі незворотні деструктивні зміни. Доведено, що використання ліофілізованої ксеношкіри після ранньої некректомії уражених тканин помітно зменшує вміст токсичних продуктів у плазмі крові, запобігає розвитку деструктивних змін в компонентах серця в ранні терміни досліду, активізує регенераторні процеси, що сприяють відносній нормалізації судинного русла, скоротливих та ендокринних міоцитів передсердь і вушок серця в пізні терміни експерименту.
2012-04-20
2020-04-04
Updated: 2025-12-08
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