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0413U001129,
к.мед.н.
19-12-2012
o
Features of pharmacological activity of analgesic drugs in conditions of experimental depression
Khomiak Elena Valeriyvna,
popup.head Mamchur Vitaliy Iosifivich
popup.opponent Ярош Олександр Кузьмич
popup.opponent Волощук Наталія Іванівна
Дисертаційну роботу присвячено експериментально-теоретичному обґрунтуванню створення нових комбінацій неопіоїдних аналгетиків та антидепресантів на підставі дослідження їх аналгетичної активності, антидепресантних властивостей та впливу на поведінкові реакції у інтактних тварин та в умовах модельованої депресії. Встановлено, що в інтактних тварин найбільш ефективними за силою дії аналгетиками проявили себе диклофенак, мелоксикам, целекоксиб, парацетамол; антидепресивну активність мали - парацетамол (300 мг/кг), целекоксиб (25 мг/кг) та диклофенак (10 мг/кг). При депресії аналгетичний ефект НПЗЗ та їх комбінацій з амітриптиліном посилювався, а антидепресантний - зменшувався у порівнянні з ефектами у інтактних щурів. Проаналізовано нейрофізіологічні ефекти дії оптимальних комбінацій препаратів та їх складових на структури мозку.
2012-12-19
2020-04-04
Updated: 2025-12-08
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