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Total number
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0499U001380,
к.х.н.
28-05-1999
o
Synthesis of glycoside and pseudoglycoside derivatives of 6-azauracil and 6-azacytosine
Ognyanyk Stepan Sergijovych,
popup.head Шаламай А.С.
popup.opponent Мірошниченко М.С.
popup.opponent Приказчикова Л.П.
Нуклеозидні похідні 6-азапіримідинів та їх ациклічних аналогів. Розробка методів синтезу глікозидних та псевдоглікоздних похідних 6-азапіримідинів, вивчення структури і властивостей синтезованих сполук. Хроматографія, УФ-, ПМР-спектроскопія, елементний аналіз. Розроблено зручний одностадійний варіант синтезу похідних 6-азапіримідину методом "силільної конденсації". Встановлено закономірності глікозилювання та алкілювання заміщених 6-азапіримідинів в умовах силільного методу синтезу нуклеозидів. Галузі використання - біоорганічна хімія, медицина.
2000-12-20
2021-03-17
Updated: 2025-12-08
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