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0820U100280,
Доктор філософії
07-10-2020
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Morphofunctional characteristic of multicellular tumor spheroids enriched with cancer stem cells.
Herheliuk Tetiana S.,
popup.head Ostapchenko Lyudmila I
popup.opponent Kolybo Denys V.
popup.opponent Zavelevych Mykhailo P.
popup.review Garmanhuk Ludmila V.
popup.review Bielinska Iryna V.
Представлена дисертаційна робота присвячена вивченню морфологічних, ростових та біохімічних особливостей функціонування СПК в комплексі з пухлинними клітинами на моделі багатоклітинних пухлинних сфероїдів, отриманих з клітин моношарової культури аденокарциноми молочної залози лінії MCF-7 за умов модифікації мікрооточення. в результаті виконання дисертаційної роботи було досліджено ключові морфологічні, ростові і біохімічні параметри клітинних популяцій багатоклітинних пухлинних сфероїдів лінії MCF-7, збагачених СПК. Доведено наявність СПК в моделі, оцінено рецепторний та енергетичний статуси пухлинних клітин та їхню чутливість до протипухлинної терапії і факторів пухлинного мікрооточення. Використання культури зБПС дозволяє підвищити передбачуваність ефективності і токсичності препаратів щодо популяцій власне пухлинних клітин в комплексі з СПК ще до того, як ліки перейдуть до клінічних випробувань. Окрім цього, культура зБПС дає можливість оцінювати безпеку і вплив ліків в умовах більш наближених до умов пухлини, ніж на моделі моношарових (2D) культур і дозволяє усунути відмінності у видах, які часто перешкоджають інтерпретації доклінічних результатів, дозволяючи тестувати лікарські засоби безпосередньо в системах людського походження.
2020-10-22
2021-03-17
Updated: 2025-12-08
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