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0822U100017,
Доктор філософії
24-12-2021
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Molecular genetic markers of myocardial hypertrophy in athletes specializing in endurance sports
Polishchuk Anna Oleksandrivna,
popup.head Dosenko Viktor Evhenovuch
popup.head Drozdovska Svitlana Bohdanivna
popup.opponent Dorofeeva Olena Evginivna
popup.opponent Piven Oksana Oleksandrivna
popup.review Korobeynikova Lesya Grihorivna
popup.review Ilyin Volodumur Mukolayevich
Дисертаційна робота присвячена дослідженню ролі поліморфізмів генів та довгих некодуючих РНК в молекулярно-генетичних механізмах адаптації міокарда до тривалих інтенсивних фізичних навантажень, встановлення пошуку молекулярно-генетичних маркерів схильності до розвитку гіпертрофії міокарда. У роботі вперше охарактеризовано участь поліморізмів генів родини PPAR (PPARA, PPARG, PGC1A), UCP2, ACTN3 і СOL12A1 в адаптаційному процесі серцево-судинної системи до інтенсивних фізичних навантажень. Методом полімеразної ланцюгової реакції у реальному часі було проведено генотипування ДНК висококваліфікованих спортсменів та встановлено частоту зустрічі алельних варіантів генів-кандидатів у вказаній вибірці. Результати дозволили вперше розробити спосіб прогнозування розвитку гіпертрофії міокарда у спортсменів в залежності від поліморфізмів генів (COL12A1, PPARA, PPARG та UCP2) та отримано патент № 141030 «Спосіб прогнозування розвитку гіпертрофії міокарда у спортсменів в залежності від поліморфізмів генів». Це дає можливість проводити ранню неінвазивну діагностику патологічних станів серця у спортсменів, які спеціалізуються у видах спорту з проявом витривалості.
2022-01-04
2022-03-09
Updated: 2025-12-07
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