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Information × Registration Number 0823U100662, PhD dissertation Status Доктор філософії Date 28-08-2023 popup.evolution e Title Coordination compounds of Platinum(II), Palladium(II) and Ruthenium(II) bearing functionalized derivatives of 2-(1H-1,2,4-triazol-3-yl)pyridine. Author Yuliia M. Ohorodnik, popup.head Rostyslav D. Lampeka popup.opponent Oleksandra M. Kozachkova popup.opponent Olena V. Prysiazhna popup.review Volodymyr M. Amirkhanov popup.review Illia O. Huralskyi Description The thesis is devoted to the synthesis, characterization of the structure and physicochemical properties of the coordination compouns of Platinum (II), Palladium (II) and Ruthenium (II) with functionalized derivatives of 2-(1H-1,2,4- triazol-3-yl)pyridine. The complexes were constructed according to the cisplatinsimilarity principle (ie, “me-too” drugs) in order to improve the cytotoxicity of metal-based complexes. The substitution of two amine ligands for one diamino chelatic ligand was the first minor change. The central atom variation was the second type of cisplatin core modification. The synthesized compounds were fully characterized in solid state and in solutions. The antiproliferative properties in vitro of synthesized complexes were evaluated for five different cell lines. The first chapter of the work contains a review of the litreture, which highlights the characterization of new 1,2,4-triazole derivatives and platinum group metals. New trends in development of complexes of Platinum (II), Palladium (II) and Ruthenium (II) with N,N-bidental chelatic ligands were described, ie new Palladium (II) compound as catalysts for the C-C, C-N crosscoupling reactions and as new luminescent materials for their use as emitters in various devices. Nevertheless, the main motif of the first chapter is cytotoxic materials and the mechanism of their action. However, due to high general7 toxicity and the development of resistance of the cell lines towards platinum drug, investigation of cisplatin analogues is slill relevant. The second chapter of the work is the description of experimental procedures for lidands and coordination compounds preparation. Column chromatography details and spectral parameter-structure relationships are mentioned. The equipment used for carrying out instrumental measurements is described. Registration Date 2023-09-22 popup.nrat_date 2023-09-22 Close