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Information × Registration Number 2116U004441, Article popup.category Thesis Title popup.author popup.publication 01-01-2016 popup.source_user Сумський державний університет popup.source http://essuir.sumdu.edu.ua/handle/123456789/45180 popup.publisher Sumy State University Description Human and animal kidneys are the efferent organs which provide support of the organism with water electrolytic balance, acid-base and osmotic homeostasis. It has been studied from literary sources that the development of early stage of poliuria acute renal failure 72 hours after administration of mercury chloride is characterized by activation of lipid peroxide oxidation with increasing content of diene conjugates and malonic aldehyde in the cortical substance of the kidneys. This stage of the pathological process is accompanied by increased glomerular filtration rate and urine output compared with the period of oliguria, but as compared with the control of these parameters it was noted decrease in glomerular filtration and urine output. Water and salt loading were carried out 2 hours before euthanasia, intragastrically through a metal tube. 2 hours after loading the animals were decapitated under the light ether anesthesia. Mercury chloride intoxication of animals was conducted subcutaneously by aqueous solution of mercury chloride (II) at a dose of 5 mg per kg body weight. popup.nrat_date 2025-05-12 Close