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Information × Registration Number 2116U004523, Article popup.category Thesis Title popup.author popup.publication 01-01-2016 popup.source_user Сумський державний університет popup.source http://essuir.sumdu.edu.ua/handle/123456789/44949 popup.publisher Sumy State University Description Background: HIV-1 infection results in marked immunologic insults, including pronounced CD4+ T-cell loss from gut lymphoid tissue, and structural damage to the intestinal mucosa following dysfunction of the gastrointestinal system, including compromised barrier function. Increased intestinal permeability and microbial translocation promote systemic immune activation, which is implicated in disease progression. While the development of highly active antiretroviral therapy (HAART) has been a major advancement in the treatment of HIV-1 infection, the need for novel complementary interventions to help repair intestinal structural and functional integrity remains unmet. Known properties of probiotics suggest that they may be useful tools in restoring normal intestinal flora. In this regard, the aim of the present study was to evaluate changes in microflora of the large intestine in chronic HIV infection and the possibility of correction by means of bacterial preparations (probiotics). popup.nrat_date 2025-05-12 Close