Search academic texts

Information × Registration Number 2117U001537, Article popup.category Стаття Title popup.author popup.publication 01-01-2017 popup.source_user Сумський державний університет popup.source http://essuir.sumdu.edu.ua/handle/123456789/66332 popup.publisher Сумський державний університет Description Гіпотиреоз – захворювання, що характеризується поліморфністю клінічних симптомів. На тлі гіпотиреозу зазнають змін всі без винятку органи і системи. Гипотиреоз – заболевание, характеризующееся полиморфностью клинических симптомов. На фоне гипотиреоза изменяются все без исключения органы и системы. Hypothyroidism is a disease characterized by polymorphism of clinical symptoms. Hypothyroidism influences absolutely all organs and systems. An important pathogenetic factor in the occurrence of atherosclerosis with hypothyroidism is the vascular cell adhesion molecule (VCAM-1). In this case, the expression of vascular VCAM-1 adhesion molecules in vascular endothelium occurs, which leads to the adhesion of monocytes and blood lymphocytes to activated endothelial cells, their transposition to the subendothelial layers, persistence of the inflammatory process in the vascular wall, and the progression of endothelial dysfunction. There is evidence of the relationship between VCAM-1 and markers of dyslipidemia, a metabolic syndrome. However, the contribution of VCAM-1 to atherogenesis and the formation of vascular lesions in the hypothyroidism conditions has not been practically studied. popup.nrat_date 2025-03-24 Close