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Information × Registration Number 2120U005351, Article popup.category Thesis Title popup.author popup.publication 01-01-2020 popup.source_user Сумський державний університет popup.source https://essuir.sumdu.edu.ua/handle/123456789/78062 popup.publisher Sumy State University Description It is known that Atherosclerosis is one of the major cause of mortality in our time, but despite this, the exact therapy and pathogenesis have not been developed. This pathology is caused by local changes of the vascular wall and general disorders of lipid metabolism that cause lipoidosis of the inner lining of the arteries. With slow stenosis of the arteries, there is a gradual replacement of the functional tissue to the connective tissue, which leads to myocardial infarction, ischemic stroke or hypertrophy. Science doesn’t know how to stay and always move from one point to another, so recent studies by Kiss-Toth and Johnston show that the TRIB1 protein (Tribbles pseudokinase 1), which is present in macrophages, increases the number of receptors for LDL, which promotes the development of the disease. Also other researchers have found a correlation between atherosclerosis and thyroxine levels in the blood, suggesting that measuring thyroid hormones may help identify patients at risk of atherosclerosis. popup.nrat_date 2025-05-12 Close