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Information × Registration Number 2120U006369, Article popup.category Стаття Title popup.author popup.publication 01-01-2020 popup.source_user Сумський державний університет popup.source https://essuir.sumdu.edu.ua/handle/123456789/79155 popup.publisher ALUNA Description Одним із незалежних факторів розвитку серцево-судинних ускладнень є гіпертрофія лівого шлуночка. З кожним роком з’являється все більше публікацій, які доводять, що ця проблема є генетично обумовленою. Одним из независимых факторов развития сердечно-сосудистых осложнений является гипертрофия левого желудочка. С каждым годом появляется все больше публикаций, доказывающих, что эта проблема является генетически обусловленной. One of the independent factors of development of cardio-vascular complications is in left ventricular hypertrophy. Each year more and more publication appear that prove this problem is genetically determined. Aim of the study was to find dependence of left ventricular hypertrophy indexes to polymorphism of Les198Asn gene endothelin-1 and BMI. Materials and methods. We took research in 160 patients with arterial hypertension, using ECG and polymerase chain reaction (PCR). Groups were divided additionally according to BMI (body mass index). Results. It was found, that patients with obesity had their Left ventricular mass and hypertrophy left ventricular indexes higher, than in patients with normal and increased body weight. Carriers of Asn198Asn and Lys198Asn genotypes Left ventricular mass and hypertrophy left ventricular indexes are higher than in carriers of Lys198Lys genotype. Conclusions. It was determined that in patients-carriers of Asn198Asn genotype, Left ventricular mass (LVMI) and hypertrophy left ventricular indexes (LVMMI) were higher compared to patients-carriers of Lys198Lys and Lys198Asn type, both in men and women. The dependence of LVMI and LVMMI are shown to be higher in patients with obesity than in people with normal and increased body mass. popup.nrat_date 2025-05-12 Close