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Information × Registration Number 2122U005589, Article popup.category Стаття Title popup.author Molotkovets V.Medvediev V.Korsak A.Chaikovsky Y.Marynsky G.Tsymbaliuk V. popup.publication 09-12-2022 popup.source_user Національний медичний університет імені О. О. Богомольця popup.source http://ir.librarynmu.com/handle/123456789/4673 popup.publisher Neurophysiology Description Mechanical damage to the peripheral nerves, especially their transection, is a serious disabling injury, treatment of which and rehabilitation related to the consequences of such traumas are an urgent and important medical/social problem. In experiments on animals, we evaluated the effectiveness and safety of multiple-point epineural connection of segments of the transected sciatic nerve using an electric welding technology. Left-side transection of the above nerve at a middle third of the thigh was performed in adult albino mongrel male rats. The experimental groups were the following: intact animals (I, n = 5), those subjected to sham surgery (Sh, n = 6), rats with neurotomy and no additional interventions (NT, n = 21), neurotomy + epineural neurorrhaphy (NT+NR, n = 18), and neurotomy + electric welding of the nerve segments (NT+EW, n = 21). It was found that the EW connection provided fast and reliable fixation of the nerve segments with subsequent significant recovery of transmission via the injured nerve and progressing partial normalization of morphological characteristics of the fibers within a regenerative neuroma at the site of nerve transection; indices characterizing the density of nerve fibers and mean angle of their deviation from the longitudinal nerve axis were the best in the NT+EW group. Most intense positive changes in the sciatic functional index (SFI), an integrative index characterizing the level of functional disorders of locomotion-related movements performed by the hindlimb at the NT side, were observed in the NT+NR and NT+EW groups. Our data clearly showed that the efficiency of the welding connection of an injured nerve is at least not lower than that provided by neurorrhaphy; the dynamics of recovery after both operations are quite comparable. The EW connection is much simpler and does not require an exclusively high qualification of the surgeon; in the case of operations on nerves in humans, the respective surgery will require less time and will be less expensive. popup.nrat_date 2025-06-30 Close