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Information × Registration Number 2124U000699, Article popup.category Стаття Title popup.author popup.publication 01-01-2024 popup.source_user Інституційний репозитарій (електронний архів) Київського національного університету імені Тараса Шевченка popup.source https://ir.library.knu.ua/handle/15071834/5206 popup.publisher Elsevier BV Description Contemporary research in the field of microbiota shows that commensal bacteria influence physiological activity of different organs and systems of a human organism, such as brain, lungs, immune and metabolic systems. This influence is realized by various processes. One of them is trough modulation of immune mechanisms. Interactions between microbiota and the human immune system are known to be complex and ambiguous. Dendritic cells (DCs) are unique cells, which initiate the development and polarization of adaptive immune response. These cells also interconnect native and specific immune reactivity. A large set of biochemical signals from microbiota in the form of different microbiota associated molecular patterns (MAMPs) and bacterial metabolites that act locally and distantly in the human organism. As a result, commensal bacteria influence the maturity and activity of dendritic cells and affect the overall immune reactivity of the human organism. It then determines the response to pathogenic microorganisms, inflammation, associated with different pathological conditions and even affects the effectiveness of vaccination popup.nrat_date 2024-12-16 Close