Search academic texts

Registration Number

0221U101243, 0118U003042 , R & D reports

Title

To study impairments of central transmitter-metabolic mechanisms of the brain plasticity in alcohol dependence and to develop methods for their correction

popup.stage_title

Head

Berchenko Olga G., Доктор біологічних наук

Registration Date

18-01-2021

Organization

State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine"

popup.description2

Code NAMN.MP.6F.18 ALCOHOLIC DEPENDENCE, NEUROPLASTIC, NEUROPHYSIOLOGICAL, NEUROMEDIATORY, NEUROTROPHIC, HORMONAL MECHANISMS, EXERCISE, SODIUM NITROPRUSIDE Object of study - 222 laboratory rats. Objective – to study limbic-neocortical, central and peripheral mediator-hormonal and neurotrophic mechanisms of functional changes in neuronal plasticity in rats with alcohol dependence and to develop approaches for their correction. Methods - neuroethological, neurophysiological, biochemical, mathematical. List of measuring equipment - Annex A. In rats with alcohol dependence at the systemic and mediator-hormonal levels, neu-roplastic rearrangements of the mechanisms of regulation of functional brain activi-ty with weakening of inhibitory processes were revealed. It is established that dis-turbances of various parts of catecholaminergic, GABA-ergic, neurosteroid, neu-rotrophic systems of the brain support alcohol dependence and emotional and cog-nitive disfunctions. The value of the basic level of anxiety in the formation of alco-hol dependence is shown. It is proved that dosed physical activity and intranasal administration of nitric ox-ide donor - sodium nitroprusside promote positive changes in neurochemical mech-anisms of plasticity, suppress the craving for alcohol, restore or compensate for brain function depending on the action of the corrective factor and the level of anxi-ety. Dosed physical load promotes improving cognitive processes based at the res-toration of BDNF functions. Correction of anxiety is conditioned by specific gluco-corticoid regulation of inhibitory and neurotrophic processes in the brain.

Product Description

popup.authors

Veselovskaya Olena V
Prihodko Olena Olena O.
Titkova Anna Anna M.
Shlyakchova Anna V

popup.nrat_date

2021-01-18