Registration Number
0221U101243,
0118U003042
, R & D reports
Title
To study impairments of central transmitter-metabolic mechanisms of the brain plasticity in alcohol dependence and to develop methods for their correction
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Head
Berchenko Olga G., Доктор біологічних наук
Registration Date
18-01-2021
Organization
State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine"
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Code NAMN.MP.6F.18
ALCOHOLIC DEPENDENCE, NEUROPLASTIC, NEUROPHYSIOLOGICAL, NEUROMEDIATORY, NEUROTROPHIC, HORMONAL MECHANISMS,
EXERCISE, SODIUM NITROPRUSIDE
Object of study - 222 laboratory rats.
Objective – to study limbic-neocortical, central and peripheral mediator-hormonal and neurotrophic mechanisms of functional changes in neuronal plasticity in rats with alcohol dependence and to develop approaches for their correction.
Methods - neuroethological, neurophysiological, biochemical, mathematical.
List of measuring equipment - Annex A.
In rats with alcohol dependence at the systemic and mediator-hormonal levels, neu-roplastic rearrangements of the mechanisms of regulation of functional brain activi-ty with weakening of inhibitory processes were revealed. It is established that dis-turbances of various parts of catecholaminergic, GABA-ergic, neurosteroid, neu-rotrophic systems of the brain support alcohol dependence and emotional and cog-nitive disfunctions. The value of the basic level of anxiety in the formation of alco-hol dependence is shown.
It is proved that dosed physical activity and intranasal administration of nitric ox-ide donor - sodium nitroprusside promote positive changes in neurochemical mech-anisms of plasticity, suppress the craving for alcohol, restore or compensate for brain function depending on the action of the corrective factor and the level of anxi-ety. Dosed physical load promotes improving cognitive processes based at the res-toration of BDNF functions. Correction of anxiety is conditioned by specific gluco-corticoid regulation of inhibitory and neurotrophic processes in the brain.
Product Description
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Veselovskaya Olena V
Prihodko Olena Olena O.
Titkova Anna Anna M.
Shlyakchova Anna V
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2021-01-18
