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Information × Registration Number 0222U000124, 0121U107435 , R & D reports Title Synthesis and study of fused heterocyclic systems containing the 7-deazapurine fragment popup.stage_title Head Smolii Oleh B., д.х.н. Registration Date 03-01-2022 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2  Approaches to the synthesis of new functionalized 7-deazapurine derivatives and fused pyrrolo[2,3-d]pyrimidines have been developed. Based on methyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate effective methods have been found for the preparation of 3,4,5-functionally substituted 7-deazapurine derivatives. It was shown for the first time that the bromination reaction products of 4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid and its methyl ester proved to be convenient reagents for obtaining new tricyclic derivatives of 1-deazapyrimido[1,2,3-cd]purine, promising for further targeted synthesis of previously unknown biologically active compounds. Product Description popup.authors Biletsky Igor І. Verves Evgeniy V. Gayevsky Anatoly P. Zinchenko Hanna M. Kucher Oleksandr V. Muzychka Lyubov V. Yaremchuk Iryna О. popup.nrat_date 2022-03-09 Close