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Information × Registration Number 0210U005523, 0110U001691 , R & D reports Title Novel surface biochemical markers of animal and human cell death (apoptosis): mechanism of appearance and biomedical applications popup.stage_title Head Bilyy Rostyslav Olexandrovych, Registration Date 16-12-2010 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 It was shown that increase in exposure of galactose- and mannose-containing glycans and decreased exposure of sialil-containing glycoproteins on plasma membranes (PM) of apoptotic cells is related to 1) modification of already existent glycoproteins paspase-activated neuraminidases on cellular surface; 2) merging of endoplasmic reticulum membranes bearing immature glycans with PM , 3) but not due to synthesis of glycoproteins de novo. Technologies for artificial removal of apoptotic cells were developed: 1 - by artificial desialylation of apoptotic cells with subsequent enhancement of their phagocytosis by macrophages; 2 - by the use of lectin-functionalized magnetic nanocarriers specific to apoptotic cells. Results were published in 1 Ukrainian patent application, 1 article was accepted to printing, 3 articles were prepared for submission, 6 theses were published. Product Description popup.authors Білий Ростислав Олександрович Філяк Євген Зиновійович popup.nrat_date 2020-04-02 Close