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Information × Registration Number 0219U000064, 0115U001380 , R & D reports Title Creation of a molecular system for the delivery of specific proteins to tumor cells based on the study of the interaction of gold nanoparticles with proteins of different classes popup.stage_title Head Kashuba Olena Vitaliivna, Доктор біологічних наук Registration Date 10-01-2019 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 During the project, it was shown that the high level of protein TR53 associated with glutathione-sepharose, which had previously been eluted and immobilized on the surface of various forms of NP, causes apoptosis in PC3 and PNT2 cells, with varying efficacy. At simultaneous administration of protein MRPS18-2, synergy of apoptosis caused by protein ТР53 was observed. The synergy of apoptosis is more pronounced when using NP of the form of balls than the nanourchins at the expense of a more stable three-dimensional structure. It has been shown that the MRPS18-2 protein on the surface of the NP exacerbates tumor cell apoptosis induced by a high level of TP53 protein. The synergy of apoptosis is more pronounced when using NP of the form of balls than the nanourchins at the expense of a more stable three-dimensional structure. Such an effect may increase the effectiveness of chemotherapy. Product Description popup.authors Кашуба Олена Віталіївна Ковалевська Лариса Миколаївна popup.nrat_date 2020-04-02 Close