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Registration Number

0120U104883, ( 0221U101020  0222U001056  0224U000419  ) R & D request

Title

Enzymes of post-translational modifications of microtubule proteins as targets for inhibition of the excitability of primary nociceptive neurons

Head

Karpov Pavlo A., Доктор біологічних наук

Registration Date

13-11-2020

Organization

Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine

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The main goal of the project is to determine the role of enzymes involved in posttranslational modifications (PTM) of microtubule elements, in the modulation of ion channels of excitable cells of the Peripheral Nervous System (PNS) and the search for pharmacological means of influencing these molecular targets. The ability to regulate the activity of enzymes such as HDAC6, aTAT1, TTLL1 or ELP3 complex, can be used for innovative correction of disorders that occur in chronic pain conditions of various etiology.

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2024-12-10