Registration Number
0123U100778,
R & D request
Title
Study of the therapeutic potential of modified MSCs and their extracellular products at separate and combined use
Head
Kordium Vitalii A., д.б.н.
Registration Date
02-02-2023
Organization
Institute of Molecular Biology and Genetics of NAS of Ukraine
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The aim of the work is to study the therapeutic effect of modified MSCs and their extracellular products. Because the
composition of microvesicles is very dynamic, there is an opportunity to manipulate it using modified MSCs as a source of
microvesicles. During research, it is expected to obtain and study the features of the biological and therapeutic effect of human
umbilical cord MSCs modified by various factors; development of optimal options for accumulation of extracellular
microvesicles by modified MSCs, their fractionation, quality assessment; study of the therapeutic effectiveness of both modified
MSCs and their extracellular products; evaluation of the combined therapeutic effect of modified MSCs and their secreted
products, separate use of microvesicles obtained after cultivation of modified MSCs. Therapeutic effects will be investigated on
model pathologies of various genesis in laboratory animals. Based on the results of the research, the principles of the use of
MSCs and their extracellular products, as a medicinal product will be formed, which involves the comprehensive realization of
the therapeutic potential of both directly MSCs and their extracellular products. In the course of the study, molecular biological,
biochemical, immunological and histological methods and cell biology methods will be used
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2024-12-09
