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Information × Registration Number 0123U101110, ( 0224U032361  0225U003486  ) R & D request Title The role of the thiol-disulfide system in the implementation of neurodestruction/neuroprotection mechanisms and the development of pharmacological modulation pathways after prenatal hypoxia Head Belenichev Ihor Fedorovych, Доктор біологічних наук Registration Date 15-02-2023 Organization Zaporizhzhya State Medical University popup.description1 Еxperimentally substantiate the use of modulators of thiol-disulfide system (glutathione, glutaredoxine, and derivatives of selenium, tiazotate, and cysteine), as well as heat shock factor 1 (HSF-1) in the management of consequences of prenatal CNS hypoxia on the basis of experimental data revealing the role of the thiol-disulfide system in the interruption of NO-; IL-1b; ROS-dependent mechanisms of neurodestruction and excitotoxicity and SH/HSP70 – mediated regulation mechanisms of endogenous neuroprotection. popup.nrat_date 2024-12-09 Close