Registration Number
0123U101110,
(
0224U032361
0225U003486
)
R & D request
Title
The role of the thiol-disulfide system in the implementation of neurodestruction/neuroprotection mechanisms and the development of pharmacological modulation pathways after prenatal hypoxia
Head
Belenichev Ihor Fedorovych, Доктор біологічних наук
Registration Date
15-02-2023
Organization
Zaporizhzhya State Medical University
popup.description1
Еxperimentally substantiate the use of modulators of thiol-disulfide system (glutathione, glutaredoxine, and derivatives of selenium, tiazotate, and cysteine), as well as heat shock factor 1 (HSF-1) in the management of consequences of prenatal CNS hypoxia on the basis of experimental data revealing the role of the thiol-disulfide system in the interruption of NO-; IL-1b; ROS-dependent mechanisms of neurodestruction and excitotoxicity and SH/HSP70 – mediated regulation mechanisms of endogenous neuroprotection.
popup.nrat_date
2024-12-09
