Registration Number
0123U104256,
(
0224U031448
0224U032711
)
R & D request
Title
Development of semi-industrial protocols for the synthesis of functionalized carboranes – a promising platform for biomedical applications
Head
Rassukana Yuliia V., Доктор хімічних наук
Registration Date
18-10-2023
Organization
Institute of Organic Chemistry NAS of Ukraine
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1. To elaborate convenient cost-efficient protocols for semi-industrial scale synthesis of ortho- meta- and para-disubstituted carboranes.
2. To design a chemical toolbox for the synthesis of functionalized carboranes for needs of medicinal chemistry and material science.
3. To conduct ADME/PK profiling of the carborane-based analogues of the compounds with well-studied biological activity.
4. To prove the concept of the bioisosteric relationships between carborane and benzene cores.
popup.nrat_date
2024-12-09
