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Information × Registration Number 0125U002857, ( 0226U002209  ) R & D request Title Preclinical study of the antifibrotic effect of novel heterocyclic inhibitors of TGF-b, JAK1 and JAK2 in scleroderma models Head Ivasechko Iryna I., Доктор філософії Registration Date 02-07-2025 Organization Institute of Cell Biology of the National Academy of Sciences of Ukraine popup.description1 The main goal of the research planned in the project is to study the antifibrotic activity of new heterocyclic compounds, inhibitors of transforming growth factor beta (TGF-β), which plays a key role in the pathogenesis of fibrosis, Janus kinases 1 and 2 (JAK1 and JAK2), which in scleroderma contribute to inflammation, fibroblast activation, and collagen deposition in mono- and combination therapy of scleroderma/skin fibrosis, to evaluate their efficacy, selectivity, and safety in cell and animal models, and to determine optimal combinations of these inhibitors to create innovative therapeutic strategies aimed at reducing fibrotic changes and restoring tissue functions. popup.nrat_date 2025-07-02 Close