Registration Number
0125U002857,
(
0226U002209
)
R & D request
Title
Preclinical study of the antifibrotic effect of novel heterocyclic inhibitors of TGF-b, JAK1 and JAK2 in scleroderma models
Head
Ivasechko Iryna I., Доктор філософії
Registration Date
02-07-2025
Organization
Institute of Cell Biology of the National Academy of Sciences of Ukraine
popup.description1
The main goal of the research planned in the project is to study the antifibrotic activity of new heterocyclic compounds, inhibitors of transforming growth factor beta (TGF-β), which plays a key role in the pathogenesis of fibrosis, Janus kinases 1 and 2 (JAK1 and JAK2), which in scleroderma contribute to inflammation, fibroblast activation, and collagen deposition in mono- and combination therapy of scleroderma/skin fibrosis, to evaluate their efficacy, selectivity, and safety in cell and animal models, and to determine optimal combinations of these inhibitors to create innovative therapeutic strategies aimed at reducing fibrotic changes and restoring tissue functions.
popup.nrat_date
2025-07-02
