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Information × Registration Number 0125U003284, ( 0225U003984  ) R & D request Title Fine structural alterations of the neurogenic niche in Alzheimer’s disease Head Tsupykov Oleh M., Доктор медичних наук Registration Date 09-09-2025 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description1 This project aims to explore the intricate morphological interactions between adult neural stem cells (aNSC) and their neurogenic niche, specifically investigating the alterations in Alzheimer's disease (AD). Focusing on two key questions, the study seeks to understand changes in structural interactions between aNSC, astrocytes, and microglia in AD using a common mouse model. Additionally, the project examines the impact of vascular amyloidosis on aNSC perivascular processes, exploring potential dysregulation of proliferation in the context of AD. By employing advanced microscopy techniques, this research aims to uncover crucial insights into the pathogenesis of AD, offering a foundation for understanding aNSC regulation within the neurogenic niche. popup.nrat_date 2025-09-09 Close