Registration Number
0126U003439,
R & D request
Title
Molecular mechanisms of reciprocal interaction between signaling pathways dependent on the adaptor protein Ruk/CIN85 and the plasminogen activation system in the control of tumor cell malignancy.
Head
Людмила Б. Дробот, д.б.н.
Registration Date
09-04-2026
Organization
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine
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The aim of this project is to elucidate the molecular mechanisms of reciprocal interaction between signaling pathways dependent on the adaptor protein Ruk/CIN85 and the plasminogen activation system (uPA/uPAR/PAI-1) in the control of redox-homeostasis, autophagy, transcriptome/metabolome in tumor cells involved in the development of cancer stem cells (CSCs) features, progression of tumor growth, and metastasis, as well as to identify new promising therapeutic targets and prognostic markers.
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2026-04-09
