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Information × Registration Number 0203U000552, 0100U000917 , R & D reports Title To develop a dosage form of protein-free immunotrophic factor splenosid,to study its specific activity and establish normative and techical documents for the remedy popup.stage_title Head Tron'ko M.D.,Olijnyk B.V., Registration Date 21-02-2003 Organization V.P.Komisarenko Institute of Endoсrinology and Metabolism popup.description2 Protein-free immunotropic factor obtained of the spleen and preclinically studied with a low molecular weight and pronounced mitosisstimulated activity of relatively nature T-cell subpopulation of the lymphoid organs and the blood is presented by a substance as a capsular (experimental) form of preparation "Splendid" for internal usage. A correspondence of specific (T-lymphocytosisstimulated and antiallergenic activity of the substance and samples of finished medicinal capsular form of preparation) was shown by the modern physical-chemical, isotope, immunological and pharmacological methods. The relative composition of structure provides bioavailability in the intestine and the quantitative determination in active factor of preparation. T- lymphocytosisstimulated action of preparation in the cell culture can be possible test for determine its biological activity. Antiallergenic action of preparation "Splenosid" as a index of its specific activity is realized on the model of allergic reaction of immediate type in mices. As a whole the work that was fulfilled composes the scientific and technician basis for the creation of medicinal immunotropic remedy for internal usage. Metabolic product, nucleoside nature, high therapeutic efficacy at absolute harmless and antiallergenicity, an absence of commulativity and erethism possibility to internal use by single (one) preparation or in the complex with other remedies, simplicity in manufacture and the presence of source of raw materials at the absence of direct analogues substantially adventiously differ the preparation "Splenosid" from othe peptide as well as synthetic immunomodulators. Product Description popup.authors popup.nrat_date 2020-04-02 Close