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Information × Registration Number 0203U002212, 0100U001373 , R & D reports Title The study of the influence of synthetic muramyldipeptides structure and structure of natural triterpenoids on their biological activity. popup.stage_title Head Chirva Vasily Yakovlevich, Registration Date 07-02-2003 Organization National Taurida V. Vernadsky University popup.description2 Subject of the scientific study were: - Development of synthesis scheme to obtain the new muramyldipeptides, biological activity of newly synthesized MDP analogues and structure-function interrelation in their molecules. - A study of new approaches to the synthesis of 1,2-trans-glucosaminides, and also of other key intermediates, which can be used to obtain muramylpeptides and other biologically active compounds. - Isolation, ascertainment of structure and biological properties of triterpene glycosides from nature sources unstudied before. The aim of investigation: - Synthesis of new muramyldipeptides using previously obtained data for structure-function interrelation in MDP molecule and their biological activity. - Development of new synthesis methods of 1,2-trans-glycosides and other aminosugars derivatives, which in particular are indispensable to simplify and to cheapen of muramylpeptides synthesis. - A search of new sources of triterpene glycosides with potential bioactivity among plants of Araleacea. An obtaining of their structure information and biological activity data. On the base of our previously obtained on structure-function interrelation in MDP molecule data a new double functinalized muramylpeptide was synthesized and this compound was under production tests as a stimulator of safety and living weight augmentation of broilers. Synthesis of new muramyldipeptide derivatives with chromonic aglycones - glycopeptides having fluorescent on glycosidic center was carried out. It was fulfilled synthesis of new muramydilpeptides derivatives: (-hexyl-, (-cyclohexyl-, (-phenylglycosides of MDP, and also hydrophobic (-n-tolyl- and n-tret-butylphenylglycosides of MDP. Influence of the muramylpeptides glycosides on Interlewkin-2 production and antiinfection resistance stimulation. It were developed a new method of obtaining 1,2-trans-glycosides and 1,2-cis-1-O-acyl derivatives of 2-acylamino-2-deoxysugars and also selective N-deacylation method in the row of aminosugars. All method are based on formationof active intermediate - 2-mthylglyco-[2,1-d]-2-oxazolinium halide. A new method of ,2-trans-glycosaminides synthesis using (2-methoxyethyl)glycosides of aminosugars as glycosilating agents was realized. A new method of glycosidic hydroxyl protection based on anomeric O-alkylation of O,N-acylated aminosugars semiacetales was proposed. Triterpene glycosides of plant origin were studied to search new physiologically active substances and to ascertain structure-function interrelation. The plant sources of substances with hemolytic and psychotropic activities were characterized. The melting points are determined with a PTP device. The optical rotation was measured with a Polamat-A polarimeter. 1H-NMR spectra are received on Bruker WP-200 (200 MHz), Varian Geminy-200 (200 MHz), Varian VXR-300 (300 MHz) and Bruker WМ-500 (500 MHz) spectrometers. TLC on the Kieselgel 60-F254 (Merck) and Silufol UV-254 (Kavalier) plates. Column Chromatography was performed with Aldrich 70 - 230 mesh, Merck 240 - 400 mesh and L-40/100(Lachema) silica gel. The obtained substances can be used in research institutes and organizations engaged in questions of immunology, creation of vaccines, prophylactic, and also development of methods of preventive maintenance of diseases of an agricultural animal. Product Description popup.authors popup.nrat_date 2020-04-02 Close