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Information × Registration Number 0204U000217, 0101U001450 , R & D reports Title To study the mechanisms of transformation of myelodysplastic syndrome into leukemia in persons suffered from the Chernobyl accident in remote period popup.stage_title Head Klymenko Viktor Ivanovich, Registration Date 22-01-2004 Organization Research Centre for Radiation Medicine popup.description2 The object of investigation: children and adults with MDS and leukemias transformed from MDS.The aim of study was to find the peculiarity of cellular, subcellular and molecular disturbances in myelodysplastic syndrome and their role in the development of radiation-induced leukemia in persons suffered from the Chernobyl accident, in remote period. The methods were clinical, morphological,immunological, citogenetical, molecular and mathematical. The connection between the changes of immune system, cytogenetic abnirmalities and changes of protoonkogenes in persons suffered frof the Chernobyl accident was established. The degree of the dysplastic changesdepended from MDS type. The significant changes were founded in themegakariocyte's lineage. The immunological reaction was wrong at early stages of antigene reception and cells interactiom because of changes antigens' expression with simultaneous reducing of B-lymphocytes. It was founded the high sensitivity to the apoptosis in MDS-RAEB and MDS-RA. Simultaneous expresion lineage antigenes om myeloid CD34+33+ cells or lymphoid progenitors confirm the exsistence of wide opportunity fot the changes of direction and speed of differentiation after the humoral and cells interaction. The degree of cytogenetic abnormalities ( typical for MDS - (inv(16), 5q-, -7, 11р-, 12р-, del/inv(16), 20q-, 1р-, 3р-, 3q- and nontypical - 5p-, 7p-, 9q-, der21) depended from type pf MDS and were the highest in AML post MDS. The secondary type of MDS confirmed the high frequency of structure abnormalities of chromosome 3 (3q26 in RA,RAEB) and structure and quantitative abnormalities of chromosome 7 (7q26-q32 (RAEB). The molecular investigation in patients with MDS and AML transfortmed from MDS, revealed the point mutations of p53 gene and non reliable changes of bcl-2 protein. Product Description popup.authors popup.nrat_date 2020-04-02 Close