Registration Number
0205U002103,
0102U002283
, R & D reports
Title
The study of age features in the metabolic adaptation to the influence of damaging oxidative stress factors and create differential methods of antioxidant therapy.
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Head
Davidov V.V., Кандидат технічних наук
Registration Date
28-01-2005
Organization
Institute of Children and Adolescents Health Care of AMS of Ukraine
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Subject: oxidative stress, metabolism of aldehydes, resistance to free radical damage. Objective: to study the role of aldehyde catabolism enzymes as regards age changes of the organism resistance to oxidative stress. Methods: spectrophotometry, spectrofluorimetry, differencial centrifugation. Theoretical and practical results, novelty: in the development certain conditions are formed in the liver and in the skeletal muscle of rats to change aldehyde dehydrogenase and aldehyde reductase function during immobilization stress. The conditions manifested themselves through specific strain related to aldehyde utilization in aldehyde reductase reaction in the liver of 1,5-month-old rats, and through delay in their utilization in aldehyde dehydrogenase and aldehyde reductase reaction in the muscle. The role of these enzymes activation and biosynthesis stimulation is supposed to be these increasing the resistance to oxidative stress.
Product Description
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2020-04-03
