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Information × Registration Number 0205U002105, 0102U002288 , R & D reports Title Study clinic-pathogenetic peculiarities of diabetes mellitus process combining with thyroid pathology in children and adolescents for perfecting effectivity of thear treatment popup.stage_title Head Filipova Neonila, Registration Date 28-01-2005 Organization Institute of Children and Adolescents Health Care of AMS of Ukraine popup.description2 Subject: 362 children with DM, in connection with thyropathies being present. Objective: optimization of approaches to the treatment of diabetes mellitus with concomitant thyropathies in children and adolescents through exact determining the mechanisms of forming combined variants of the disease course in childhood and adolescence. Methods: conventional clinical, instrumental (USI, ECG, RVG, REG), biochemical, radioimmune (T3, T4, TTH, cortisol, STG, antibodies to (-cells), immunologic (T- and B-lymphocytes, T-lymphocyte subpopulations, phagocytosis, immunoglobulins, CIC and antithyroid antibodies). Teor. and pract. results, novelty: there was revealed a significant incidence of thyroid pathology in children with diabetes mellitus, irrespective of sex. It has been proved that presence of autoimmune thyroiditis in patients with type I diabetes mellitus in childhood is characterized by a less prominent loss of insulin residual secretion by (-cells, by persistence of expressed or subclinical hypothyreosis, as well as by certain rise in cortisol content in girls and in patients with autoimmune thyroiditis formed from the moment of diabetes mellitus manifestation. It was established that immune thyroiditis in children was characterized by inhibition of T-cells and phagocytal links of immunity as well as by an increase in the share of B-lymphocyte with an increased formation activity of antibodies to thyroid gland tissue, and insular apparatus of the pancreas, especially due to antibodies to glutamat decarboxilase. Immunologic and hormono-metabolic shifts revealed in children with DM in combination with thyropathies cause some difficulties in achieving optimal carbohydrate metabolism compensation due to lability of glycemia fluctuations and lead to severe course of the disease and early formation of diabetic complications. There was proved the necessity of thyropathy screening in all the children with DM as well as the expediency of active using of thyrotropic therapy in patients with concomitant thyropathies.Such therapy results not only in positive dynamics as regards the thyroid gland size and thyroid hormonal profile, but also in improved findings in carbohydrate metabolism compensation. Effectivenes: optimization of achieving carbohydrate metabolism satisfactory compensation and prevention of diabetic complications formation. Sphere of application: endocrinology, pediatrics. Product Description popup.authors popup.nrat_date 2020-04-02 Close