Registration Number
0206U004426,
0106U002174
, R & D reports
Title
Study the influence of nitric oxide on the neurosecretion
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Head
Malysheva Margaryta Kostiantynivna,
Registration Date
22-02-2006
Organization
Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine
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The main goal of proposed project is ascertaining of molecular mechanism of nitric oxide influence on some steps of the neurosecretory process. Effect of nitric oxide on uptake of neurotransmitter by synaptosomes via plasma membrane transporter, distribution of neurotransmitter between synaptic vesicle pool and cytosolic pool,neurotransmitter release as a result of realization of exocytotic process , the effect of nitric oxide on the last step of exocytosis - fusion of synaptic vesicles with presynaptic membrane were investigated. It is known that proteolytic enzyme calpain modifying the structural membrane proteins and cytoskeletal proteins is involved in the exocytosis.It was shown that NO inhibited enzyme activity and it was supposed that nitric oxide could be a calpain activity regulator and thus influences membrane fusion. The results obtained allow to clear molecular mechanisms of regulation of neurosecretory process by nitric oxide.5635
Product Description
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2020-04-02
