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Information × Registration Number 0207U000194, 0104U002088 , R & D reports Title To stady the osteointegration process at plastic of bone defects by calcium phosphate ceramics with different conposition and structure popup.stage_title Head Korzh M.O., Registration Date 15-01-2007 Organization Ukrainian Academy of Medical Sciences Sytenko Institute of Spine and Joints Pathology popup.description2 Aim: To study the calcium phosphate ceramics osteointegration depending on their composition and structure at the defects plastics in the areas of bone with different weigh-bearing on the base of morphological and morphometric characteristics of osteorepair process. To discover the influence of bone cavities plastics by different kind of ceramics on stress deforming state of proximal femur for formulation the requirements of differential use of implants in the clinical conditions aiming at increasing efficiency of the patients treatment. Object: rat's and rabbit's femur with creating bone cavities in the areas of bone with different weigh-bearing, proximal femur of human and its three-dimensional model, hydroxyapatite (HA) and tricalcium phosphate (TCP) ceramics. Methods: experimental, morphological with morphometry, clinical and X-ray, mathematic modeling, biomechanical, statistic. In experiments at 33 rabbits and 84 rats created bone defects (cavities) in the areas of bone with different weigh-bearing (lateral distal metaphysis of femur - more loaded zone and greater trochanter of femur - less loaded zone) were filled by ceramic speciments having different structure: dense (micropores) and porous HA granules (micropores and macropores), porous biphase (60% HA/40% TCP) granules. It was proved that the repair osteogeneis trend at implantation studied ceramic specimens did not distinguish in both distal metaphysis and greater trochanter of femur. However the processes of bone formation were influenced by not only physical and chemical features of materials but the loading conditions. Repair osteogenesis and ceramics bioresorbtion occured more intensively in more loaded zone. HA bioresorbtion was not observed. Strength of bone-ceramics union was higher in more loaded zones. Three-dimensional end-element model of proximal femur was designed. The influence of destructive cavities which were placed in the head, neck and greater trochanter of the femur, plastics these cavities by different kind of ceramics alsoon stress deforming state was explored. Significant and ambiguous influence of cavities on stress deforming state it was shown. The cavities plastic by ceramic materials normalizes stress deforming state but this process depends on ceramics composition and structure, its strength characteristics, location cavities. Clinical investigations at treatment of 144 patients (71 women and 43 men, age from 11 to 75 years) with pathology of locomotion system (aseptic necrosis of femur head, tumor and tumor-like diseases, dysontogenetic coxarthritis II stage, trauma consequence, etc.) proved high efficacy of calcium phosphate ceramics (dense and porous HA granules, porous biphase granules) use for bone cavities plastic. The necessity was proved and main regulations were formulated concerning the use of ceramics in clinic. The loading level in implantation zone, mechanical features of ceramics its structure and composition were taken into account. It was shown the differential approach for use ceramic specimens on the clinical conditions. Product Description popup.authors popup.nrat_date 2020-04-02 Close