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Information × Registration Number 0207U002812, 0102U001629 , R & D reports Title Molecular mechanisms of action and construction of biologically active substances (neurotropic, antiviral, antimicrobial) popup.stage_title Head Andronati S.A., Registration Date 16-02-2007 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 The model allowing prediction of affinity for 5-НТ1А receptors of potential ligand has been constructed on the base of multiparameter analysis of experimental data with account of the рКi, рКа and spacer length of N-(arylpiperazinealkyl)-benzoisoquinoline-1,3-dione pthalimide derivatives. According with this model the compounds with the higher affinity meet the following demands: n = 4-6 і рКа = 5,0 0,6. It has been shown that cinazepam does not interact with peripheral benzodiazepin, dopamine (D1 і D2), serotonin (5-НТ1А and 5-НТ2) and cholecystoquinin (ССК2) receptors, demonstrate high affinity for central benzodiazepin receptors. It has been shown that in mice organism the amixine is slightly biotransformed with the formation of two metabolites -2,7-dioxyfluorenon and 2-oxy-7-diethylaminoetoxyfluorenone. The high speed of absorption in organism inner media and slow process of its tissue and organ elimination are typical for amixin pharmacokinetics at peroral administration Product Description popup.authors popup.nrat_date 2020-04-02 Close