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Information × Registration Number 0207U005379, 0106U011374 , R & D reports Title Proteomic analysis of translation of genetic information in human cells popup.stage_title Head Negrutskii Boris S., Доктор біологічних наук Registration Date 05-04-2007 Organization Institute of molecular biology & genetics popup.description2 Main idea of the project is the analysis of the organization of translational proteome in human cells. Aims of the project: 1. Determination of possible partners of the components of translation machinery in human cells by TAP-Tag method. 2. Study of the intracellular mobility of the components of translation machinery in human cells by FRAP method. We first determined that multiprotein complex of aminoacyl-tRNA synthetases and the complex of elongation factor 1 ("heavy" form) exist in vivo. We determined the protein partners which interact with the components of multisynthetase complex and the proteins which interact with the components of elongation factor 1 ("heavy" form). We determined the role N-terminal domains of aminoacyl-tRNA synthetases, which provide compartmentalization of aminoacyl-tRNA synthetases. The obtained results are prepared for publication.5635 Product Description popup.authors popup.nrat_date 2020-04-02 Close