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Information × Registration Number 0207U005766, 0106U000541 , R & D reports Title Substituted amides of the triazinyl-propancarbonic acid as highly potent inhibitors of human mycosis and mycotoxicosis popup.stage_title Head Shved A.D., Registration Date 20-06-2007 Organization Institute of molecular biology & genetics popup.description2 For the first time have been developed highly effective method of triazinil-6-propancarbonic acid synthesis and the convenient technological scheme of its amides synthesis for reproduction of potential inhibitors structures constructed by molecular design methods. Ihe wide spectrum of carboxamides was obtained by directed synthesis. The first time on the model of the catalytic site of DNA-dependent RNA polymerase T7 phage by the nonimpirical method of quantum chemistry at a level of theory HF/6-31G (d, p) has been shown that such amides formated the ternary complex: RNA-polymerase-ligand-DNA-matrix. Testing of the synthesized substituted amides on model transcription system in vitro using T7 pol has been shown the efficient inhibition of RNA synthesis by some compounds. The fungistatic activity of 77 synthesised amides concerning 18 types (69 strains) that represente the different mycomicetes groups, museum and clinical strains of Candida spp has been investigated. For the further studying had been chosen a number of compounds that spectrum and the level of their activity don't concede the commercial antifungal agents. Product Description popup.authors popup.nrat_date 2020-04-02 Close