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Registration Number

0207U008865, 0106U005003 , R & D reports

Title

Development and medicine application of original anaesthetic drugs with central and peripheral mechanism of effect for treatment of somatogenetic painful syndrome with neuro-psychogenetic component.

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Head

Chaika L.,

Registration Date

26-12-2007

Organization

State scientific center of drug means

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For theoretical and experimental basis of perspective combinations of nonnarcotic analgetics with drug substances of other pharmacotherapeutical groups, foundations of combined use of traditional nonnarcotic and narcotic analgesics with neurotropic drugs were analyzed. Studies of analgesic effect of combinations of basic analgetics with neurotropic drugs with different directions of effects were conducted. It was determined that combined use of analgetics with neurotropic drugs revealed a synergism of their analgesic effect with different degree of intensity. Greatest increase of analgetic effect of combinations in comparison with effects of one-component drugs was revealed at combination of paracetamol with fluoxetine and paracetamol with gidazepam. Analgetic effect of combinations of celecoxib with neurotropic drugs substantially did not differ by the intensity from one-component drugs effect. Combined use of tramadol with neurotropic drug was accompanied by additivity and/or stabilization of analgesic effect in dynamics. Obtained and analyzed data of studies allowed to draw a conclusion about the expediency of further studies of analgesic effects of mentioned combinations under the condition of the pain, mainly with peripheric genesis, in other words, what has been initiated at acute or chronic injuries of peripheral tissues.

Product Description

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2020-04-02