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Information × Registration Number 0209U005664, 0106U001525 , R & D reports Title The study of the interrelation between vitamin D3 and estrogen receptor gene polymorphisms, osteoporosis and efficiency of its treatment popup.stage_title Head Butenko Gennadii Mihailovitch, Доктор медичних наук Registration Date 11-03-2009 Organization State Institution "Institute of Gerontology AMS Ukraine" popup.description2 160 participants (women, 48-70 years old) with different BMD are subjected to a detailed examination, which includes not only medical and BMD evaluation but also assessment of exercise physiology, body composition, nutrition, and psychology. We have examined the association of BMD and bone fractures risk at various sites with the TNF-alpha (-308 A/G), IL-10 (-1082 A/G), VDR (BsmI, TaqI) and ER1 (XbaI, PvuII) genes. No significant difference in BMD and bone fracture risk among TNF-alpha (-308 A/G) genotypes was detected in postmenopausal women. IL-10 A/A genotype significantly affected BMD as for the total body (Р=0.01), as for lumbar spine (Р=0.003), femoral neck (Р=0.04), and Ward's triangle (Р=0.01). XbaI polymorphisms of ER1 gene were associated with fracture risk in Ukrainian postmenopausal women. 27.0% of all incident fragility fractures occurring in genotype Ee, and 72.5 % - in genotype EE (р=0.04). Similar dependence was determined for BsmI polymorphisms of VDR gene: 51.0 % of all incident fragility fractures occurring in genotype bb (р=0.02). Among the different combinations, 50 % women with bbEE genotype had bone fractures (Р=0.003). Product Description popup.authors popup.nrat_date 2020-04-02 Close