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Information × Registration Number 0209U005803, 0106U011201 , R & D reports Title Modulation of nociception by cascades of G-protein activated protein kinases popup.stage_title Head Krishtal Oleg O., Доктор біологічних наук Registration Date 13-05-2009 Organization International center of molecular physiology popup.description2 We studied the interaction between -opioid, CB-1 cannabinoid and P2X2/3 receptors of sensory neurons and intracellular mechanisms, which mediate this interaction under normal and pathological conditions. It was shown that under normal conditions -opioid receptor agonists inhibit P2X2/3-mediated currents, activated by ATP, by 50% at the average via G-protein dependent mechanisms. Co-culturing of neurons with mice fibrosarcoma cells (NCTC 2472 cell line) for 2-5 days leads to significant decrease of endomorphin-1 inhibitory action on ATP-activated currents with slow desensitization kinetics. At the same time relative number of neurons with slowly desensitizing currents also increases. Besides, we studied the mechanisms of opioid modulatory influence on P-type voltage-gated calcium channels in Purkinje neurons. Our data indicate that opioids act via or receptors of a neuron, altering neuronal excitability by bimodal regulation of P-type voltage-gated calcium channels. Product Description popup.authors popup.nrat_date 2020-04-02 Close