Search academic texts

Information × Registration Number 0210U000100, 0107U001088 , R & D reports Title To study the main mechanisms in the development of chronic cardiac insufficiency in adolescents with myocardium pathology popup.stage_title Head Bogmat Lyudmila F., Доктор медичних наук Registration Date 20-01-2010 Organization Ukrainian Research Institute of Children and Adolescents Health Care popup.description2 Object of study: chronic cardiac insufficiency (CCI) in adolescents aged 10-18 with myocardium pathology (MP). Objective: improving the methods of prophylaxis of the CCI progress in children and adolescent with various cardiac pathologies on the basis of determining the character of changes in the neurohumoral regulatory systems, the process of infammation , and remodeling of the cardiovascular system. Methods: clinical, ECG, doppler-echocardio-and vascularography, stress-echoCG, biochemical, radioimmunologic, and immunofermental. Theoretical and practical results: it has been established that in children with MP the signs of CCI progressing include: desadaptive restructuring of the heart with expansion of the left ventricle (LV) and the left atrium cavities, an increased amount of residual blood at systole, a progressing decrease in the struck and minute volumes of the heart and in the LV ejection fractions. In children who had inflammatory pathologies of the myocardium said signs were registered in 55.17% of cases, and in children with dysplastic cardiomyopathy and cardiac rhythm disorders those signs were registered in 38 to 40% of cases. In 57.14% of the patients there was revealed an endothelial dysfunction, which contributed to deterioration of the compensatory capacity of the vascular system and to intensification to cardiovascular disorders. It was shown that deterioration of the systolic function of the heart and the progress of the CCI took place against the background of activation of the renin-angiotensin-aldosterone regulatory system (RAAS) and endotheline-1 of the blood. A negative dynamics of the myocardium functional capacity is also accompanied by increased levels of proinflammatory cytokines, activation of free-radical processes (increased levels of oxidative protein modifications), inadequate response of the antioxidant systems, and by reduced variability of cardiac rhythm and the quality of life. There was developed a regressive model for prognostication of the CCI progress in children with the heart pathologies, the model including the indices for neurohumoral regulation (epinephrine, norepinephrine, cortisol, renin, angiotensin-II, and plasma aldosterone). The prognostic values of individual humoral factors have been specified, as well as the role of morphofunctional characterisrics of the heart, and a decrease in the cardiac rhythm variability in the progress of systolic dysfunction of the myocardium in children. Novelty: it has been convincingly proved that in children with the myocardium pathology negative dynamics of the morphofunctional parameters of the heart is accompanied by activation of the neurohumoral regulation systems( SAS, RAAS, endotheline-I), increased levels of proinflammatory cytokines, oxide modifications of proteins, and by a changed content of cyclic nucleotides. A prognostication model of the CCI progress in children with different heart pathologies has been worked out. Effectivenes: prevention of CCI progress. Field of application: pediatric cardiorheumatology, pediatrics. Product Description popup.authors Ахназарянц Е.Л. Богмат Л.Ф. Введенська Т.С. Гуляєва В.Г. Давидов В.В. Красноруцька Н.Д. Михальчук О.Я. Молєва В.І. Ніконова В.В. Рак Л.І. Сильницька Л.Є. Толмачова С.Р. Черваньова В.О. popup.nrat_date 2020-04-02 Close