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Information × Registration Number 0210U001345, 0105U002634 , R & D reports Title Synthesis, structure, properties and molecular recognition of biologically active heterocyclic compounds and peptidomimetics by central and peripheral receptors. popup.stage_title Head Andronati S.A., Registration Date 09-02-2010 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 Analgesic activity was detected in vivo experiments in mice by the "spasms" method provoked by acetic acid in a series of 3-arylidene and 3-amino derivatives of1,2-dihydro-3H-1,4 -benzodiazepine-2-ones. Peptidomimetics, potential ligands of bradykinin receptors were synthesized. The structure is confirmed by modern physical and chemical methods. 1,2,3,4-tetrahydroizoquinaline derivative was found among the synthesized compounds that shows a high analgesic activity by the "acetic spasms" method in mice Product Description popup.authors Карасьова Т.Л. Крисько А.А. Павловський В.І. Смульський С.П. popup.nrat_date 2020-04-02 Close